Name: Poricoic Acid B (CAS 137551-39-4) - Natural Mushroom Extract
Availability: InStock
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Poricoic acid B CAS NO.137551-39-4

Poricoic Acid B is a high-purity lanostane-type triterpenoid isolated from the medicinal fungus Poria cocos(Fu Ling), standardized for research in nephrology, oncology, and metabolic disease. This natural compound is characterized by its potent dual functionality in targeting renal fibrosis pathways and exhibiting anti-tumor promoting activity, serving as a critical reference standard and active pharmaceutical ingredient (API) for preclinical development in kidney protection and chemoprevention.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Poricoic acid B
CAS NO.	137551-39-4
Appearance	White to off-white amorphous powder
Molecular Formula	C₃₀H₄₄O₅
Molecular Weight	484.67 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in methanol, DMSO, ethanol; slightly soluble in water; insoluble in n-hexane
Endotoxin	≤5 EU/mg (LAL test)
Biological Activity	Anti-fibrotic (inhibits TGF-β/Smad pathway); anti-inflammatory; modulates Wnt/β-catenin and AhR signaling; potential nephroprotective and anti-tumor promoting effects
Storage Conditions	Store at 2–8°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Poricoic Acid B exerts its primary effects by modulating key signaling pathways involved in fibrosis and inflammation. It significantly inhibits TGF-β/Smad3 phosphorylation and Wnt/β-catenin signaling to block epithelial-mesenchymal transition (EMT) and extracellular matrix deposition. Concurrently, it activates the aryl hydrocarbon receptor (AhR) and suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and oxidative stress markers, providing a multi-target approach to halt tissue scarring and chronic inflammation.

2.PRODUCT INDICATIONS

This product is indicated for scientific research applications focused on chronic kidney disease (CKD) and renal fibrosis intervention, hepatorenal metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD) models. It is also utilized in cancer chemoprevention studies targeting inflammation-driven tumor promotion (e.g., EBV-EA activation), making it suitable for researchers in nephrology, hepatology, and oncology drug discovery.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Poricoic Acid B effectively attenuates renal fibrosis in CKD models, improving kidney function markers and reducing collagen accumulation. In metabolic contexts, it ameliorates hepatic steatosis and insulin resistance. Its anti-tumor efficacy is evidenced by strong inhibition of tumor promoter-induced pathways, positioning it as a promising candidate for translational research into antifibrotic and chemopreventive agents.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: PoricoicAcidB #PoriaCocos #Triterpenoid #RenalFibrosis #TGFbetaInhibitor #NaturalProduct #CKDResearch #AntiFibrotic

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