Pramlintide Acetate CAS NO.196078-30-5/151126-32-8

Pramlintide Acetate CAS NO.196078-30-5/151126-32-8

Pramlintide Acetate CAS NO.196078-30-5/151126-32-8

Pramlintide Acetate CAS NO.196078-30-5/151126-32-8

Pramlintide Acetate CAS NO.196078-30-5/151126-32-8

Pramlintide Acetate is a synthetic peptide analog of human amylin, developed as an adjunctive injectable therapy for both type 1 and type 2 diabetes patients who use mealtime insulin. It is designed to improve glycemic control specifically in the postprandial period when insulin alone fails to achieve target blood glucose levels. The product is administered subcutaneously and works in concert with, but does not replace, insulin therapy, offering an additional mechanism to regulate glucose absorption and metabolism.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Pramlintide Acetate
CAS NO.
196078-30-5/151126-32-8
Appearance
White to off-white lyophilized powder
Molecular Formula
C171H267N51O53S2
Molecular Weight
3949.47 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility
Soluble in aqueous buffers (e.g., PBS, acetic acid); sparingly soluble in water
Endotoxin≤1.0 EU/mg
Biological Activity
Stimulates insulin secretion, suppresses glucagon, delays gastric emptying
Storage Conditions
Store at 2–8°C, protected from light; lyophilized form stable for 24 months
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Pramlintide Acetate mimics the physiological action of the natural hormone amylin, which is co-secreted with insulin by pancreatic beta cells. Its primary mechanisms include delaying gastric emptying to slow the rate of nutrient absorption, suppressing postprandial glucagon secretion to reduce hepatic glucose production, and promoting satiety via central nervous system modulation. By targeting these pathways, it addresses the rapid glucose influx after meals, complementing the peripheral glucose disposal effects of exogenous insulin.

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2.PRODUCT INDICATIONS

This product is indicated as an adjunct therapy for adults with type 1 diabetes or type 2 diabetes who are treated with mealtime insulin. It is specifically targeted at patients who have not achieved adequate glycemic control despite optimized insulin regimens, including those who may also be using oral antidiabetic agents. It is contraindicated in patients with a history of hypoglycemia unawareness or gastroparesis, and requires careful patient selection and training to mitigate the risk of severe hypoglycemia.

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3.CLINICAL EFFICACY OF PRODUCT

Clinical studies have demonstrated that Pramlintide Acetate, when added to insulin therapy, provides a significant reduction in postprandial glucose excursions and leads to a modest but consistent decrease in HbA1c levels (approximately 0.5% to 1.0%). A notable secondary benefit is weight loss or the mitigation of insulin-associated weight gain, with type 2 diabetes patients experiencing an average reduction of 1.5 to 2.5 kg. This makes it a valuable option for patients struggling with both hyperglycemia and weight management.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

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