Prepro-Atrial Natriuretic Factor (26-55) (human) CAS NO.112160-82-4
Prepro-Atrial Natriuretic Factor (26-55) (human) CAS NO.112160-82-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Prepro-Atrial Natriuretic Factor (26-55) (human) |
| CAS NO. | 112160-82-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C152H236N38O51S3 |
| Molecular Weight | 3508g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1-1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This peptide corresponds to a bioactive fragment of the human prepro-ANF precursor, capable of activating natriuretic peptide receptors (primarily NPR-A), stimulating guanylyl cyclase activity, and increasing intracellular cGMP levels. It exhibits vasodilatory, natriuretic, and diuretic effects in appropriate bioassay systems. |
| Storage Conditions | Lyophilized powder: Store at –20°C or below in a desiccated environment, protected from light. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide acts primarily by binding to natriuretic peptide receptors, especially NPR‑A, which are membrane‑bound guanylyl cyclase‑coupled receptors. Ligand–receptor engagement stimulates intracellular guanylyl cyclase activity, leading to a rapid increase in cyclic GMP (cGMP) levels. Elevated cGMP activates cGMP‑dependent protein kinases, resulting in vasodilation, enhanced renal sodium and water excretion (natriuresis and diuresis), and suppression of the renin–angiotensin–aldosterone system. Through these integrated pathways, the peptide helps reduce vascular resistance, lower cardiac preload and afterload, and restore fluid‑electrolyte balance, thereby serving as a key modulator of cardiovascular and renal physiology.
2.PRODUCT INDICATIONS
This human prepro‑ANF (26‑55) peptide is indicated for research use only in preclinical investigations of natriuretic peptide biology, cardiovascular regulation, and related disorders. It is employed as a specific agonist in receptor‑binding assays, cGMP accumulation studies, and in vitro models of vascular relaxation and renal tubular transport. The peptide is also used in animal models to evaluate hemodynamic, natriuretic, and diuretic responses in conditions such as hypertension, heart failure, and volume overload. Furthermore, it serves as a reference standard for developing ANF‑based diagnostics or therapeutics. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Prepro-Atrial Natriuretic Factor (26-55) (human) does not possess established clinical efficacy for therapeutic use in human patients. This synthetic peptide has not undergone clinical development or received regulatory approval for any medical indication. While studies using this peptide have contributed to the understanding of natriuretic peptide pathways and potential therapeutic targets for cardiovascular diseases, the product itself remains an investigational tool for basic and translational research. It has no proven clinical efficacy or safety profile in humans and is strictly intended for laboratory research applications.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.