Name: Prepro-Atrial Natriuretic Factor (26-55) Human CAS 112160-82-4
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Prepro-Atrial Natriuretic Factor (26-55) (human) CAS NO.112160-82-4

Prepro-Atrial Natriuretic Factor (26-55) (human) is a synthetic peptide corresponding to residues 26–55 of the human prepro-ANF precursor, representing a biologically active region involved in cardiovascular and fluid‑homeostasis regulation. This high‑purity research‑grade peptide is produced under stringent quality controls and supplied as a lyophilized powder, making it an essential tool for studying natriuretic peptide signaling, receptor interactions, and the molecular mechanisms underlying blood‑pressure control and sodium–water balance. Its well‑defined sequence and consistent activity support reproducible experiments in both cell‑based assays and animal models, providing valuable insights for academic and drug‑discovery research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Prepro-Atrial Natriuretic Factor (26-55) (human)
CAS NO.	112160-82-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C152H236N38O51S3
Molecular Weight	3508g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1-1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide corresponds to a bioactive fragment of the human prepro-ANF precursor, capable of activating natriuretic peptide receptors (primarily NPR-A), stimulating guanylyl cyclase activity, and increasing intracellular cGMP levels. It exhibits vasodilatory, natriuretic, and diuretic effects in appropriate bioassay systems.
Storage Conditions	Lyophilized powder: Store at –20°C or below in a desiccated environment, protected from light. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide acts primarily by binding to natriuretic peptide receptors, especially NPR‑A, which are membrane‑bound guanylyl cyclase‑coupled receptors. Ligand–receptor engagement stimulates intracellular guanylyl cyclase activity, leading to a rapid increase in cyclic GMP (cGMP) levels. Elevated cGMP activates cGMP‑dependent protein kinases, resulting in vasodilation, enhanced renal sodium and water excretion (natriuresis and diuresis), and suppression of the renin–angiotensin–aldosterone system. Through these integrated pathways, the peptide helps reduce vascular resistance, lower cardiac preload and afterload, and restore fluid‑electrolyte balance, thereby serving as a key modulator of cardiovascular and renal physiology.

2.PRODUCT INDICATIONS

This human prepro‑ANF (26‑55) peptide is indicated for research use only in preclinical investigations of natriuretic peptide biology, cardiovascular regulation, and related disorders. It is employed as a specific agonist in receptor‑binding assays, cGMP accumulation studies, and in vitro models of vascular relaxation and renal tubular transport. The peptide is also used in animal models to evaluate hemodynamic, natriuretic, and diuretic responses in conditions such as hypertension, heart failure, and volume overload. Furthermore, it serves as a reference standard for developing ANF‑based diagnostics or therapeutics. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Prepro-Atrial Natriuretic Factor (26-55) (human) does not possess established clinical efficacy for therapeutic use in human patients. This synthetic peptide has not undergone clinical development or received regulatory approval for any medical indication. While studies using this peptide have contributed to the understanding of natriuretic peptide pathways and potential therapeutic targets for cardiovascular diseases, the product itself remains an investigational tool for basic and translational research. It has no proven clinical efficacy or safety profile in humans and is strictly intended for laboratory research applications.

4.DELIVERY & SHIPPING

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