![[Pro9] Substance P CAS NO.104486-69-3](https://images.cnmqh.com/images/a10134/b8bb8a194f16bd56c1761c3d2734738d-20260302005505.webp "[Pro9] Substance P CAS NO.104486-69-3")
[Pro9] Substance P CAS NO.104486-69-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Pro9] Substance P 104486-69-3 |
| CAS NO. | 104486-69-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C66H102N18O13S |
| Molecular Weight | 1387.73g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water and dilute acids; partially soluble in ethanol |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Acts as a neuropeptide and neurotransmitter involved in pain transmission, inflammation modulation, and vascular permeability regulation; stimulates NK1 receptor-mediated signaling pathways |
| Storage Conditions | Store at -20°C protected from light and moisture; stable for 24 months under recommended conditions |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action of [Pro9] Substance P involves its high-affinity binding to the G protein-coupled Neurokinin-1 (NK-1) receptor. Upon binding, it activates phospholipase C, leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol triphosphate (IP3) and diacylglycerol (DAG). This cascade elevates intracellular calcium levels, which facilitates neuronal excitation, neurotransmitter release, and the initiation of inflammatory responses, effectively mimicking the physiological effects of the native peptide.
2.PRODUCT INDICATIONS
[Pro9] Substance P is primarily indicated for use in preclinical and in vitro research applications. It serves as a critical pharmacological tool for investigating the role of NK-1 receptors in conditions such as chronic pain, neurogenic inflammation, and stress-related disorders. Researchers utilize it to study the mechanisms underlying emesis (vomiting), mood regulation, and the neuro-immune axis in various experimental models.
3.CLINICAL EFFICACY OF PRODUCT
In clinical research contexts, [Pro9] Substance P has demonstrated efficacy as a challenge agent, inducing dose-dependent wheal and flare responses in human skin when administered intradermally. This validates its potent biological activity and utility in studying local inflammatory mediators. While not a therapeutic agent itself, its high potency (EC50 of 0.93 nM) makes it instrumental in validating the efficacy of NK-1 receptor antagonists and understanding the pathophysiology of neuroinflammatory diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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