Sennoside B CAS 128574 High Purity API Suppliers and Factory in China
Sennoside B (CAS NO. 128-57-4) is a high-purity dianthrone glycoside and potent stimulant laxative utilized extensively in pharmaceutical formulations. Functioning as a sophisticated prodrug, it remains inactive in the upper gastrointestinal tract, ensuring targeted delivery to the colon where it is metabolized by anaerobic bacteria into the active form, rhein anthrone, to effectively stimulate colonic motility and fluid secretion.
Engineered for pharmaceutical-grade applications, our Sennoside B is essential for the development of OTC laxatives, syrups, and suppositories, as well as critical bowel preparations for diagnostic colonoscopies. Beyond its primary laxative use, it serves as a vital analytical benchmark for phytochemists and is being explored in non-clinical research for its neuroprotective and anti-PDGF properties, ensuring the highest standards of therapeutic efficacy and regulatory compliance.
Detailed Parameters
| Product Name | Sennoside B | CAS NO. | 128-57-4 |
|---|---|---|---|
| Appearance | Light yellow to yellow crystalline powder | Molecular Formula | C42H38O20 |
| Molecular Weight | 862.74 g/mol | Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in DMSO, NaHCO₃ solution | Endotoxin | < 10 EU/mg |
| Storage | Store at 2-8°C or -20°C | Stock Location | USA Stock Available |
Key Advantages
GMP Compliance
Produced within GMP-compliant systems ensuring rigorous quality control from raw materials to final packaging.
Rapid Efficacy
Proven clinical success in producing bowel movements within 6 to 12 hours of administration.
High Purity
RP-HPLC purity ≥95% provides consistent batch-to-batch stability for critical pharmaceutical research.
Targeted Action
Prodrug mechanism ensures localized activation in the colon, reducing systemic absorption risks.
Full Traceability
Every batch includes a comprehensive COA, HPLC reports, and MS chromatograms for total transparency.
Global Logistics
Specialized international air freight via DHL/FedEx ensures temperature-controlled, secure delivery.
Product Gallery
Management Platforms
Quality Management
Implementation of rigorous internal quality systems to ensure API stability and purity.
GMP Production
Collaboration with FDA and DMF certified manufacturers for industrial-scale supply.
Batch Traceability
Comprehensive documentation and tracking for every gram produced and shipped.
Regulatory Support
Providing all necessary analytical benchmarks and certificates for regulatory submission.
Inventory Control
Optimized USA-based stocking to reduce lead times for North American partners.
Custom Synthesis
Flexible production capabilities ranging from milligram research levels to ton-level industrial supply.
Investment Return Comparison
| Evaluation Metric | Generic Laxatives | Sennoside B (Premium) |
|---|---|---|
| Activation Site | General GI Tract | Targeted Colonic Action |
| Patient Tolerance | Moderate (Nausea Risk) | High (Reduced Side Effects) |
| Onset Time | Variable | Consistent 6-12 Hours |
| Purity Level | Standard Grade | Pharmaceutical Grade (≥95%) |
| Compliance | Basic Standards | GMP/FDA Aligned |
Frequently Asked Questions
Sennoside B acts as a prodrug that is hydrolyzed by anaerobic bacteria in the colon to yield rhein anthrone. This metabolite stimulates the myenteric plexus to enhance peristaltic contractions and inhibits Na+/K+-ATPase pumps to increase fluid secretion, facilitating easier defecation.
To ensure long-term stability and purity, it should be stored at temperatures between 2-8°C or -20°C, protected from light and moisture, and kept in a tightly sealed container.
Yes, we collaborate with GMP, DMF, and FDA certified manufacturers, allowing us to provide a scalable supply chain ranging from gram-level research quantities to ton-level industrial production.
Each batch is accompanied by a complete quality dossier, including a Certificate of Analysis (COA), RP-HPLC purity reports, and mass spectrometry (MS) chromatograms.
It is primarily indicated for short-term relief of occasional constipation and as a bowel cleansing agent prior to diagnostic procedures like colonoscopies and sigmoidoscopies.
Unlike bulk-forming agents that increase stool mass, Sennoside B is a stimulant laxative that actively triggers smooth muscle contractions and increases fluid secretion in the colon, typically offering faster and more potent results.
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