![[Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat CAS NO.122018-58-0](https://images.cnmqh.com/images/a10134/f8d67803f0bf0671aea862f20af97f4f-20260129075325.webp "[Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat CAS NO.122018-58-0")
[Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat CAS NO.122018-58-0
[Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat CAS NO.122018-58-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat |
| CAS NO. | 122018-58-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C72H104N20O17 |
| Molecular Weight | 1521.7g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute acetic acid (e.g., 0.1%), or phosphate-buffered saline (PBS). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 1-5 mg/mL stock solution, then dilute further with the desired assay buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This peptide corresponds to an immunodominant epitope of myelin proteolipid protein (PLP), specifically modified with a Serine substitution at position 140 and provided in a de-palmitoylated form. It is widely used in research on autoimmune demyelinating diseases, such as experimental autoimmune encephalomyelitis (EAE), to study T-cell responses and immune tolerance mechanisms. |
| Storage Conditions | Lyophilized powder: Store at -20°C or below in a desiccated environment, protected from light, for long-term stability. Reconstituted solution: Aliquot and store at ≤ -20°C. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves this peptide serving as an antigenic epitope that can be presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells to T-cells. The serine substitution at position 140 (replacing the natural palmitoylated cysteine) and de-palmitoylation modify the peptide's structure and potentially its immunogenicity compared to the native PLP sequence. When administered to susceptible animal models, this peptide can induce T-cell activation and proliferation, leading to an autoimmune response against myelin components. This T-cell-mediated immune response can result in inflammation, demyelination, and neurological symptoms characteristic of experimental autoimmune encephalomyelitis (EAE), making this peptide a tool for studying the immunopathogenesis of demyelinating diseases.
2.PRODUCT INDICATIONS
This PLP peptide analog is indicated for research use only in preclinical studies investigating autoimmune demyelinating diseases, neuroimmunology, and T-cell-mediated autoimmunity. It serves as an immunogenic peptide for inducing experimental autoimmune encephalomyelitis (EAE) in various animal models (mouse, rat, etc.) to study the pathogenesis of multiple sclerosis-like diseases. The product is used in T-cell proliferation assays, cytokine profiling studies, and investigations of immune tolerance mechanisms. The availability of species-specific variants (human, bovine, dog, mouse, rat) makes it particularly valuable for comparative immunology studies, cross-species reactivity assessments, and translational research. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, [Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated) does not have established clinical efficacy for therapeutic use in human patients. This peptide analog is used exclusively as an experimental tool to induce autoimmune disease in animal models for research purposes. It has not undergone clinical development or received regulatory approval for any medical indication. While studies using this peptide have contributed to the understanding of autoimmune demyelinating diseases and potential therapeutic targets, the product itself has no proven clinical efficacy or safety profile for human use. It is intended solely for laboratory research applications in appropriate scientific settings and should not be used in clinical contexts.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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