Name: Setmelanotide CAS 920014-72-8 - Effective Weight Management
Availability: InStock
Rating: 4.5 (89 reviews)

Setmelanotide CAS NO.920014-72-8

Setmelanotide is a targeted therapeutic agent specifically designed for the treatment of rare genetic forms of obesity, offering a novel approach to weight management by addressing the underlying neuroendocrine dysregulation. It is indicated for patients with confirmed genetic deficiencies in the melanocortin-4 receptor (MC4R) pathway, providing a mechanism to restore appetite control and energy balance that is often unresponsive to conventional diet and exercise interventions. This product represents a significant advancement in precision medicine for metabolic disorders, catering to individuals with specific genetic profiles such as POMC, PCSK1, or LEPR deficiencies, as well as Bardet-Biedl syndrome.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Setmelanotide
CAS NO.	920014-72-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C49H68N18O9S2
Molecular Weight	1117.3 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, phosphate buffer (pH 5-7), and 0.9% sodium chloride injection
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective melanocortin-4 receptor (MC4R) agonist; reduces appetite and increases energy expenditure.
Storage Conditions	Store at 2-8°C, protected from light and moisture. After reconstitution, use immediately or store as directed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Setmelanotide functions as a potent and selective agonist of the melanocortin-4 receptor (MC4R), which is a key regulator of appetite and energy expenditure in the hypothalamus. By binding to and activating MC4R, it mimics the action of endogenous α-melanocyte-stimulating hormone (α-MSH), thereby restoring downstream signaling pathways that are impaired in certain genetic obesity syndromes. This activation leads to a reduction in hunger sensation and an increase in satiety, helping to normalize food intake and promote weight loss in patients with specific MC4R pathway defects.

2.PRODUCT INDICATIONS

This product is indicated for chronic weight management in adult and pediatric patients aged 2 years and older with obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed loss-of-function biallelic proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency. It is specifically designed for individuals who have been diagnosed with these rare genetic conditions and is not intended for use in the general obese population or for obesity due to other causes.

3.CLINICAL EFFICACY OF PRODUCT

Clinical trials have demonstrated that setmelanotide leads to significant and sustained weight reduction in patients with rare genetic obesities, with many patients achieving a mean percent change in BMI of over 10% from baseline. The therapy has shown efficacy in reducing hyperphagia (excessive hunger) and improving quality of life measures. Long-term studies indicate that the weight loss and hunger control benefits are maintained over extended periods, with a manageable safety profile that includes common side effects such as injection site reactions and skin hyperpigmentation.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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