SH2 Domain Ligand (3)
SH2 Domain Ligand (3)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | SH2 Domain Ligand (3) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C82H122N15O27PS |
| Molecular Weight | 1813.03g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water or suitable buffer to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | SH2 Domain Ligand (3) is a peptide or peptidomimetic designed to bind with high affinity and selectivity to a specific SH2 domain (e.g., Src, Grb2, PI3K, etc.). It is used in biochemical and cellular assays to study SH2‑mediated protein‑protein interactions, signal transduction pathways, and as a tool for inhibitor screening. Activity is validated by SH2 domain binding assays (e.g., SPR, competitive ELISA). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This ligand functions by competitively binding to the phosphotyrosine recognition pocket of its target SH2 domain, disrupting the natural interaction between the SH2-containing protein and its phosphorylated binding partners. This blockade prevents the recruitment of downstream effector proteins to activated receptors or scaffolds, thereby inhibiting specific signaling cascades such as PI3K/AKT, Src family kinase pathways, or other SH2-dependent networks without directly affecting catalytic kinase activity, allowing for clean mechanistic dissection of pathway dependencies.
2.PRODUCT INDICATIONS
SH2 Domain Ligand (3) is indicated for research use in studying SH2 domain biology, including competitive binding assays (SPR, ITC, ELISA), cellular pathway inhibition experiments, high-throughput screening for SH2 domain inhibitors, and validation of SH2-dependent phenotypes in cancer models, immune cell activation, and developmental signaling. It is suitable for in vitro biochemical characterization and cell-based functional studies across academic, pharmaceutical, and biotechnology research settings.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool compound, SH2 Domain Ligand (3) is not intended for clinical application and has no established human efficacy data. Preclinical studies demonstrate its utility as a pharmacological probe to validate specific SH2 domains as therapeutic targets, showing dose-dependent inhibition of SH2-mediated signaling events, reduced downstream pathway activation, and modulation of cellular phenotypes in proof-of-concept experiments, supporting its role in drug discovery and target validation pipelines rather than direct therapeutic use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.