Name: Succinyl-Endothelin-1 Peptide for Targeted Therapy 142569-99-1
Availability: InStock
Rating: 4.5 (89 reviews)

Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21) CAS NO.142569-99-1

Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21), widely known in research as IRL-1620 or Sovateltide, is a potent and highly selective synthetic peptide agonist targeting the Endothelin B (ET_B) receptor. This modified fragment of Endothelin-1 is engineered with specific amino acid substitutions (Glu9, Ala11,15) and an N-terminal succinyl group to enhance receptor specificity and metabolic stability. It is extensively utilized in cardiovascular, neurological, and oncology research to study vasodilation, cerebral blood flow regulation, and neuroprotection mechanisms, serving as a critical tool for investigating ET_B-mediated signaling pathways in both in vitro and in vivo models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21)
CAS NO.	142569-99-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C₈₆H₁₁₇N₁₇O₂₇
Molecular Weight	1821.0g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, DMSO, or 1M acetic acid
Endotoxin	≤1 EU/mg
Biological Activity	Selective ET_Breceptor agonist (Ki ~16 pM)
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

IRL-1620 functions by selectively binding to the Endothelin B receptor (ET_B) with high affinity (Ki ≈ 16 pM), while exhibiting minimal interaction with the ETA receptor subtype. Upon binding, it activates G_q-protein coupled signaling, leading to phospholipase C activation, intracellular calcium mobilization, and the production of nitric oxide (NO) and prostacyclin via endothelial cells. This cascade results in potent vasodilation, increased local blood flow, and modulation of vascular permeability. Its mechanism is distinct from full-length endothelin-1, as it avoids the vasoconstrictive effects typically mediated by ETA receptors, making it a precise pharmacological tool for isolating ET_Breceptor functions in experimental settings.

2.PRODUCT INDICATIONS

This peptide is indicated for preclinical research applications focused on the endothelin system, particularly for studies investigating cerebral ischemia, stroke, neurodegenerative diseases, and cancer. Researchers use IRL-1620 to explore its potential neuroprotective effects, angiogenesis modulation, and targeted drug delivery strategies that leverage ET_Breceptor overexpression in tumor vasculature. It is suitable for academic, pharmaceutical, and biotechnology laboratories engaged in drug discovery for cardiovascular disorders, neurovascular coupling, and conditions where selective ET_Breceptor activation is therapeutically relevant.

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3.CLINICAL EFFICACY OF PRODUCT

Although not approved for clinical use, IRL-1620 has demonstrated significant efficacy in numerous preclinical models. Studies have shown that it can improve neurological outcomes and reduce infarct volume in rodent models of cerebral ischemia and stroke by enhancing cerebral blood flow. In oncology research, it has been investigated for its ability to enhance the delivery of chemotherapeutic agents to tumors via ET_Breceptor-mediated vascular effects. The peptide’s high selectivity and potency make it a valuable benchmark compound for validating the therapeutic potential of ET_Breceptor targeting in early-stage translational research.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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