Name: TRH Free Acid CAS 34367-54-9 | High Purity Chemical Solution
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TRH, Free Acid CAS NO.34367-54-9

TRH, Free Acid is the non-amidated, linear form of thyrotropin-releasing hormone, provided as a high-purity white to off-white lyophilized powder for neuroendocrine and pharmacological research. It serves as a critical tool for investigating the structure-activity relationship of TRH, studying peptide amidation processes, and exploring metabolism of neuroendocrine peptides, with distinct biochemical properties compared to its amidated counterpart.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	TRH, Free Acid
CAS NO.	34367-54-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C16H21N5O5
Molecular Weight	363.4 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). Recommended to dissolve in sterile water or 0.1% acetic acid to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	TRH (free acid) is the non‑amidated form of thyrotropin‑releasing hormone. It exhibits reduced affinity for the TRH receptor compared to the amidated form, but is used in studies of TRH metabolism, structure‑activity relationships, and as a precursor in synthetic or enzymatic amidation reactions. Bioactivity can be validated in receptor‑binding or pituitary‑cell stimulation assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide variant binds to TRH receptors on pituitary thyrotrophs with lower affinity than the amidated form, still activating Gq/11 signaling to increase intracellular calcium, albeit with reduced potency in stimulating TSH and prolactin secretion. It primarily serves as a substrate for peptidylglycine α-amidating monooxygenase, enabling studies of C-terminal amidation, and as a metabolic probe to investigate TRH degradation pathways in biological systems.

2.PRODUCT INDICATIONS

TRH, Free Acid is indicated for research applications in peptide biochemistry and neuroendocrinology, including studies of TRH biosynthesis and amidation, structure-activity relationship investigations, enzyme substrate characterization, and metabolic pathway analysis. It is suitable for academic and pharmaceutical research focused on peptide processing mechanisms, neuroendocrine regulation, and the development of TRH-related analogs.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade biochemical tool, TRH, Free Acid has no established clinical efficacy or therapeutic application. Its value lies exclusively in preclinical research where it facilitates understanding of TRH processing, metabolism, and structure-function relationships, without any approved or intended use for human treatment or clinical intervention.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.