![[Trp3,Arg5]-Ghrelin (1-5) CAS NO. 848442-59-1](https://images.cnmqh.com/images/a10134/3162532_55_2-20260123082643.webp "[Trp3,Arg5]-Ghrelin (1-5) CAS NO. 848442-59-1")
[Trp3,Arg5]-Ghrelin (1-5) CAS NO. 848442-59-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Trp3,Arg5]-Ghrelin (1-5) |
| CAS NO. | 848442-59-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C31H41N9O7 |
| Molecular Weight | 651.73g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water (≥10 mg/mL), dilute acetic acid, and DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A modified ghrelin fragment that acts as a selective agonist for the ghrelin receptor (GHSR-1a), with potent appetite-stimulating effects. |
| Storage Conditions | Store at -20°C to -80°C in a sealed container, protected from moisture and light. Stable for 1 year at -20°C, 2 years at -80°C. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This analog functions primarily as a Growth Hormone Secretagogue Receptor 1a (GHSR1a) agonist or partial agonist. The N-terminal 1-5 sequence of ghrelin is known to be the minimal fragment retaining binding affinity to GHSR1a, a G-protein coupled receptor. The [Trp3,Arg5] substitutions are designed to enhance receptor interaction, stability, or selectivity. Upon binding, it activates the Gq/11 signaling pathway, leading to phospholipase C (PLC) activation, inositol trisphosphate (IP3) production, diacylglycerol (DAG) release, intracellular calcium mobilization, and ultimately growth hormone (GH) release from the pituitary.
- Structure-Activity Relationship (SAR) Studies: Investigating the impact of specific amino acid substitutions (Trp3, Arg5) on receptor binding affinity, selectivity, and functional activity at GHSR1a.
- Minimal Active Sequence Research: Defining the shortest peptide sequence required for GHSR1a activation and studying the bioactivity of ghrelin fragments.
- In VitroReceptor Pharmacology: Serving as a reference ligand or tool compound in GHSR1a binding assays (competitive displacement) and functional assays (e.g., calcium flux, inositol phosphate accumulation).
- Drug Discovery: Used as a scaffold or lead compound in the design and development of novel GHSR1a agonists, antagonists, or allosteric modulators with improved pharmacokinetic properties.
- Physiological Studies: Exploring the potential biological roles of truncated ghrelin peptides in growth hormone regulation, appetite, and metabolism in preclinical models.
2.PRODUCT INDICATIONS
- Research Utility: Its value lies in basic science and drug discovery. Studies using this analog help elucidate how specific amino acids in ghrelin contribute to receptor binding and activation, guiding the rational design of future therapeutics.
- Therapeutic Target Validation: Research with such analogs validates GHSR1a as a target for conditions like growth hormone deficiency, cachexia, or obesity.
- Clinical Translation Gap: This specific peptide is not a drug candidate itself. Any clinical application would stem from the development of optimized, stable, and safe GHSR1a modulators (agonists or antagonists) whose design may be informed by studies with fragments like this one.
- Status: No clinical trials have been conducted with [Trp3,Arg5]-Ghrelin (1-5). Its efficacy is measured in terms of in vitroreceptor potency and in vivoactivity in animal models, not in human patients.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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