Type A Allatostatin II CAS NO.123338-11-4
Type A Allatostatin II CAS NO.123338-11-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Type A Allatostatin II |
| CAS NO. | 123338-11-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₄₉H₇₄N₁₄O₁₃ |
| Molecular Weight | 1067.21 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥5 mg/ml), DMSO, and dilute aqueous buffers. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Decapeptide neuropeptide; potent inhibitor of juvenile hormone (JH) synthesis by insect corpora allata; modulates feeding behavior and gut motility in insects; used for insect endocrinology and pest management research. |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark, sealed environment; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Type A Allatostatin II exerts its effects by binding to specific G protein-coupled receptors (GPCRs) of the Allatostatin A receptor family. Its mechanism involves:
- Receptor Binding & Gi/o Protein Coupling: The peptide binds with high affinity to AST-ARs on target cells (endocrine cells, neurons, muscle). Receptor activation couples to inhibitory Gi/o proteins.
- Inhibition of Adenylate Cyclase: This coupling leads to the inhibition of adenylate cyclase, resulting in a decrease in intracellular cyclic AMP (cAMP) levels.
- Suppression of Juvenile Hormone Synthesis: In the corpora allata, the drop in cAMP inhibits the enzymatic pathways responsible for juvenile hormone biosynthesis. JH is critical for maintaining juvenile stages, promoting reproduction, and regulating metamorphosis.
- Myoinhibitory & Neuromodulatory Actions: In the nervous system and visceral muscle, it reduces the frequency and amplitude of contractions (e.g., in the gut) and modulates neuronal excitability, primarily through the inhibition of cAMP-dependent pathways and potential modulation of ion channels.
2.PRODUCT INDICATIONS
This product is indicated for specialized research in invertebrate biology and applied entomology. Key applications include:
- Insect Endocrinology Research: Studying the regulation of development, metamorphosis, reproduction (vitellogenesis), and diapause via control of juvenile hormone titers.
- Insect Neurobiology & Physiology: Investigating its role as an inhibitory neurotransmitter/neuromodulator in the central and stomatogastric nervous systems, and its myoinhibitory effects on the foregut and hindgut.
- Comparative Neuropeptide Evolution: Exploring the structure and function of AST-A peptides across different arthropod species.
- Biorational Pest Control Discovery: Serving as a lead compound for designing novel, species-specific insect growth regulators (IGRs) or neuropeptide analogs that disrupt critical physiological processes in pest insects.
3.CLINICAL EFFICACY OF PRODUCT
Type A Allatostatin II is not a clinical therapeutic for humans or vertebrates. Its "efficacy" is demonstrated in the context of basic science and agricultural research.
- Validated Bioactivity: It is a well-established, potent inhibitor of JH production and a functional neuromodulator in multiple insect models, with reproducible physiological effects.
- Critical Research Reagent: It is an essential tool for dissecting complex neuroendocrine networks that control insect life cycles and behavior.
- Template for Pest Management Solutions: Research utilizing this peptide provides the molecular and physiological basis for developing innovative pest control agents. Its high specificity for insect systems makes it a promising candidate for the design of environmentally friendly, target-selective insecticides or insectistatics that interfere with development and reproduction.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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