Name: Tyr-Bradykinin CAS 32222-00-7: Potent Peptide for Research
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Tyr-Bradykinin CAS NO.32222-00-7

Tyr-Bradykinin, commonly known as [Tyr⁸]-Bradykinin, is a synthetic analog of the endogenous nonapeptide bradykinin, featuring a tyrosine substitution at position 8. This modification enhances its utility as a research tool peptide, making it a potent and selective agonist for the bradykinin B₂ receptor. It is widely used in pharmacological studies to investigate inflammatory pathways, vascular physiology, and cell signaling mechanisms, offering researchers a stable and reliable alternative to native bradykinin for in vitro and in vivo applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Tyr-Bradykinin
CAS NO.	32222-00-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₉H₈₂N₁₆O₁₃
Molecular Weight	1235.38g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water or 0.1% TFA in water; partially soluble in acetonitrile/water
Endotoxin	<0.1 EU/mg (typical specification)
Biological Activity	Potent bradykinin B₂ receptor agonist; mimics native bradykinin activity
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Tyr-Bradykinin exerts its effects by selectively binding to and activating the G protein-coupled bradykinin B₂ receptor (B₂R). This interaction triggers the Gq/11 signaling pathway, leading to phospholipase C (PLC) activation, inositol trisphosphate (IP₃) production, and subsequent calcium mobilization from intracellular stores. Additionally, it stimulates the phosphorylation of extracellular signal-regulated kinases (ERK1/2), modulating cell proliferation and inflammatory mediator release. Its mechanism closely mimics endogenous kinin activity, making it ideal for studying receptor function and downstream signal transduction.

2.PRODUCT INDICATIONS

This peptide is indicated for preclinical research in cardiovascular biology, inflammation, and pain signaling. It serves as a critical tool for studying B₂ receptor-mediated responses such as vasodilation, vascular permeability, and hyperalgesia. Researchers utilize Tyr-Bradykinin in receptor binding assays, functional studies on isolated tissues (e.g., vascular rings, ileum), and as a reference standard in the development of kinin receptor antagonists. It is particularly valuable for academic and pharmaceutical scientists focusing on hypertension, sepsis, and neuroinflammatory models.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental models, Tyr-Bradykinin demonstrates high efficacy in eliciting B₂ receptor-dependent physiological responses, including potent hypotensive effects, increased vascular permeability, and pain sensitization. Studies confirm its ability to induce ERK1/2 phosphorylation and stimulate nitric oxide release, validating its role in mimicking pathological and physiological kinin-driven processes. While not used therapeutically, its robust agonist profile provides essential preclinical data for evaluating the therapeutic potential of B₂ receptor modulation in inflammatory and cardiovascular diseases.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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