![[Tyr11] Somatostatin](https://images.cnmqh.com/images/a10134/cb93918a73a96f543de58af8d91da3c8-20260209080625.webp "[Tyr11] Somatostatin")
[Tyr11] Somatostatin
[Tyr11] Somatostatin
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Tyr11] Somatostatin |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C76H102N18O20S2 |
| Molecular Weight | 1651.91 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | [Tyr¹¹] Somatostatin is an analog of native somatostatin, modified to facilitate radiolabeling (e.g., with ¹²⁵I) while retaining affinity for somatostatin receptors (SSTR1-5). It is used primarily as a radioligand in receptor binding assays, autoradiography, and biochemical studies of SSTR-mediated signaling. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide functions as a somatostatin receptor agonist, binding to SSTR1-5 with affinity comparable to native somatostatin-14. Upon receptor engagement, it activates Gi/o proteins to inhibit adenylyl cyclase, reduce intracellular cAMP levels, and suppress calcium influx, leading to inhibition of hormone secretion and modulation of downstream signaling pathways including MAPK and PI3K/Akt. The Tyr¹¹ modification does not significantly alter receptor binding but provides an optimal site for iodination.
2.PRODUCT INDICATIONS
[Tyr¹¹] Somatostatin is indicated for research use in somatostatin receptor studies, including radioligand binding assays (competition, saturation), autoradiography of tissue sections, SSTR expression profiling, and development of receptor-targeted imaging probes. It is suitable for academic, pharmaceutical, and biotechnology research focused on neuroendocrine tumors, pituitary disorders, and SSTR-mediated signaling pathways.
3.CLINICAL EFFICACY OF PRODUCT
As a research-grade radiolabeling precursor, [Tyr¹¹] Somatostatin is not intended for clinical use and has no established human efficacy data. Its utility lies in enabling the preparation of radiolabeled tracers (e.g., ¹²⁵I-[Tyr¹¹] Somatostatin) that have been used in preclinical studies to characterize SSTR distribution, validate receptor-targeted imaging agents, and support drug discovery efforts for somatostatin-based therapeutics.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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