Name: [Tyr15] Fibrinopeptide B Human CAS 125455-56-3 High Purity
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[Tyr15] Fibrinopeptide B, human CAS NO.125455-56-3

[Tyr15] Fibrinopeptide B, human (CAS 125455-56-3) is a high-purity synthetic, site-specific analogue of the native human Fibrinopeptide B sequence (Bβ 1-14). The key modification is the incorporation of a tyrosine residue at the 15th position (a non-natural extension beyond the native cleavage site). This deliberate structural change serves a critical purpose: it provides a unique chemical handle (a phenolic -OH group on the tyrosine) for radioiodination (e.g., with I-125) or other chemical conjugations, making it an indispensable tool for developing highly sensitive immunoassays and radiometric detection methods for thrombin activity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr15] Fibrinopeptide B, human
CAS NO.	125455-56-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C75H102N20O27
Molecular Weight	1715.78 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, or 0.1% TFA in aqueous solution
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent modulator of platelet aggregation and fibrin polymerization; used in coagulation research to study thrombin-mediated fibrinogen cleavage
Storage Conditions	Store at -20°C to -80°C. Stable for 24 months when lyophilized; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as an analogue and tracer, not as a direct biological effector. Its mechanism is based on its immunological and biochemical mimicry of the native Fibrinopeptide B. After radiolabeling (e.g., with I-125 at the Tyr15 residue), it competes with unlabeled native Fibrinopeptide B (generated from a sample by thrombin cleavage) for binding sites on highly specific anti-Fibrinopeptide B antibodies in a Radioimmunoassay (RIA).

2.PRODUCT INDICATIONS

Radioimmunoassay (RIA) Tracer: As the radiolabeled tracer in competitive RIAs for the quantitative measurement of native Fibrinopeptide B in plasma, the gold-standard method for assessing in vivothrombin activity.

High-Sensitivity Assay Development: For creating ultrasensitive diagnostic kits to detect hypercoagulable states, monitor anticoagulant therapy, and research thrombosis.

Biochemical Tracer: In enzymatic studies to track fibrinogen cleavage and investigate thrombin inhibitors.

3.CLINICAL EFFICACY OF PRODUCT

As a critical component of Fibrinopeptide B RIA kits, this analogue enables the clinical diagnostic efficacy of the assay. RIAs utilizing [Tyr15]-labeled tracer are renowned for their exceptional sensitivity and specificity in measuring picomolar concentrations of native Fibrinopeptide B in patient plasma. This allows for the reliable detection of subtle, ongoing thrombin generation associated with conditions like deep vein thrombosis (DVT), disseminated intravascular coagulation (DIC), and pre-thrombotic states. Its use provides clinicians and researchers with a powerful tool for accurate thrombosis risk assessment and therapy monitoring.

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