Urotensin I CAS NO.83930-33-0
Urotensin I CAS NO.83930-33-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Urotensin I |
| CAS NO. | 83930-33-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C210H340N62O67S2 |
| Molecular Weight | 4869.55g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Urotensin I is a potent vasoactive and osmoregulatory peptide, primarily acting as an agonist for the urotensin receptor (UT, GPR14) but with distinct functional profiles compared to Urotensin II. It is involved in cardiovascular regulation, stress response, and osmoregulation. Bioactivity can be validated by vasoconstriction assays in isolated vessels or calcium mobilization assays in UT-expressing cells. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long-term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze-thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Urotensin I exerts its biological effects by binding to the urotensin receptor UT (GPR14), primarily coupling to Gq/11 to activate phospholipase C and increase intracellular calcium mobilization. This signaling cascade modulates vascular smooth muscle contraction, cardiac function, and osmoregulatory pathways, with additional effects on corticotropin-releasing factor (CRF) systems and stress response. The peptide's disulfide bridge and extended structure contribute to receptor recognition and stability, allowing it to influence diverse physiological processes including blood pressure regulation, fluid homeostasis, and neuroendocrine stress axis activation.
2.PRODUCT INDICATIONS
This peptide is indicated for research applications focused on cardiovascular physiology, osmoregulation, and stress response mechanisms. It is utilized in in vitroassays with UT-expressing cells to study calcium signaling, vasoconstriction, and receptor activation. In in vivostudies, it is administered to investigate blood pressure regulation, fluid balance, and neuroendocrine stress responses in preclinical models. The product also serves as a reference standard for receptor binding studies, immunohistochemistry, and functional assays to explore the role of the urotensin system in hypertension, heart failure, and stress-related disorders.
3.CLINICAL EFFICACY OF PRODUCT
Urotensin I has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its involvement in cardiovascular regulation and stress responses, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of stable analogs or modulators with comprehensive pharmacokinetic and safety evaluations.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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