Vasoactive Intestinal peptide CAS NO.40077-57-4
Vasoactive Intestinal peptide CAS NO.40077-57-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Vasoactive Intestinal Peptide |
| CAS NO. | 40077-57-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₂₉H₂₂₅N₄₃O₄₆S |
| Molecular Weight | 3325.57 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (≥ 1 mg/mL), dilute acetic acid or dilute hydrochloric acid; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits potent vasodilatory activity; stimulates adenylate cyclase activity in target cells (EC₅₀ typically 0.1-1.0 nM); induces smooth muscle relaxation and increases intestinal secretion |
| Storage Conditions | Store at -20°C to -80°C in a sealed container, protected from light and moisture. After reconstitution, store at 2°C to 8°C for up to 7 days, or aliquot and freeze at -20°C for long-term use . |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Vasodilation & Smooth Muscle Relaxation: In blood vessels and non-vascular smooth muscle (e.g., airways, GI tract), VIP activates adenylate cyclase, increasing cAMP. This relaxes smooth muscle, causing vasodilation, bronchodilation, and relaxation of the GI tract, reducing blood pressure and improving airflow.
Immunomodulation & Anti-inflammatory Action: VIP acts on immune cells (T-cells, macrophages, dendritic cells) to suppress pro-inflammatory cytokine production (e.g., TNF-α, IL-6, IL-12) and promote anti-inflammatory cytokine production (e.g., IL-10). It also inhibits T-cell proliferation and modulates immune tolerance.
2.PRODUCT INDICATIONS
This product is indicated for a wide range of research in physiology, pharmacology, and immunology. Key applications include:
- Cardiovascular & Pulmonary Research: Studying its role as a vasodilator in hypertension and as a bronchodilator in asthma and COPD models.
- Immunology & Autoimmunity Research: Investigating its potent anti-inflammatory and immunoregulatory effects in models of rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease (IBD), and sepsis.
- Gastroenterology: Researching its effects on gut motility, secretion, and its potential role in irritable bowel syndrome (IBS).
- Neuroscience: Exploring its neuroprotective, neurotrophic, and circadian rhythm-modulating functions.
- Receptor Pharmacology: As the definitive endogenous agonist for VPAC1 and VPAC2 receptors, used to characterize receptor signaling and screen for receptor antagonists or agonists.
3.CLINICAL EFFICACY OF PRODUCT
- Diagnostic Use: It is used in the VIPoma test to diagnose tumors that secrete VIP (VIPomas), which cause severe watery diarrhea syndrome.
- Therapeutic Potential in Autoimmunity: Preclinical studies in models of rheumatoid arthritis, multiple sclerosis, and Crohn's disease show that VIP can suppress disease activity and inflammation, making it a promising candidate for biologic therapy.
- Pulmonary Arterial Hypertension (PAH): Inhaled VIP has been investigated in clinical trials for PAH, showing potential to improve hemodynamics and exercise capacity, though development has faced challenges.
Erectile Dysfunction: VIP is a component of some compounded intracavernosal injection therapies for erectile dysfunction, used off-label in some regions.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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