Wilfordine CAS NO.37239-51-3

Wilfordine CAS NO.37239-51-3

Wilfordine CAS NO.37239-51-3

Wilfordine CAS NO.37239-51-3

Wilfordine CAS NO.37239-51-3

Wilfordine is a naturally derived sesquiterpene pyridine alkaloid extracted from the roots of the traditional medicinal plant Tripterygium wilfordii (Thunder God Vine), typically presented as an off-white to light brown crystalline powder. Characterized by its complex polycyclic structure and high purity, this research-grade compound serves as a critical tool for scientists investigating natural product pharmacology, particularly in the fields of immunology, oncology, and agricultural entomology. It is specifically suited for research professionals and formulation scientists looking to study potent immunosuppressive agents, explore novel anticancer leads that induce apoptosis, or develop botanical insecticide candidates targeting agricultural pests, offering a unique multi-disciplinary profile that bridges pharmaceutical and agrochemical research.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Wilfordine
CAS NO.
37239-51-3
Appearance
Off-white to light brown crystalline powder
Molecular Formula
C43H49NO19
Molecular Weight
883.84 g/mol
Purity (RP-HPLC)
≥98.0%
Solubility

Soluble in DMSO, methanol; slightly soluble in water

Endotoxin
≤10 EU/mg
Biological Activity
Immunosuppressive, antitumor, and insecticidal activities
Storage Conditions
Store at -20°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The biological activity of Wilfordine is driven by its ability to interfere with essential cellular signaling and enzymatic functions across different biological systems. In immunological and cancer research settings, it exerts anti-inflammatory and pro-apoptotic effects primarily by inhibiting the NF-κB signaling pathway—blocking IκBα degradation and preventing NF-κB p65 nuclear translocation—while also modulating the MAPK pathway (ERK, p38, JNK) to suppress pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6) and disrupt the Bcl-2/Bax ratio to trigger mitochondrial-dependent cancer cell death. Concurrently, in entomological applications, Wilfordine acts as a potent neurotoxin against insect larvae by directly inhibiting the Na⁺-K⁺-ATPase enzyme in the central nervous system and downregulating ryanodine receptor (RyR) expression, leading to paralysis, feeding deterrence, and mortality in target pests such as Mythimna separata and Plutella xylostella.

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2.PRODUCT INDICATIONS

This product is strictly indicated for laboratory research, preclinical pharmacological screening, and agricultural pest control studies, catering to a diverse audience that includes pharmaceutical R&D scientists, natural product chemists, immunologists, oncologists, and agrochemical researchers. It is an ideal reagent for laboratories studying the therapeutic potential of Tripterygium wilfordii constituents in autoimmune diseases (like rheumatoid arthritis) and hepatocellular carcinoma, as well as for scientists conducting bioassay-guided isolation of insecticidal compounds and evaluating dose-dependent antifeedant or contact toxicity against crop-damaging insects. Additionally, it serves as a vital analytical reference standard for quality control and chromatographic method development in botanical extract standardization.

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3.CLINICAL EFFICACY OF PRODUCT

As a raw natural alkaloid compound, Wilfordine itself is not a clinically approved drug and therefore does not possess direct clinical efficacy for human or veterinary patient administration. However, extensive in vitro and in vivo preclinical studies validate its potent bioactivity, demonstrating significant immunosuppressive, anti-inflammatory, and antitumor effects in animal models, alongside superior insecticidal potency (with 1.5 to 3.3-fold higher antifeedant and contact toxicity compared to structural analogs like wilforine) in agricultural pest models. These robust research outcomes underscore its value as a lead compound for drug discovery and a template for novel botanical insecticide development, making high-purity Wilfordine indispensable for translational research aimed at developing future therapies or pest management solutions.


4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157

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