TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Yakuchinone A exerts its effects primarily by inhibiting key inflammatory enzymes and inducing apoptosis in cancer cells. It functions as a potent inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), thereby reducing the production of prostaglandins and nitric oxide that drive inflammation. Additionally, it modulates the Bcl-2 signaling pathway, promoting apoptosis by down-regulating anti-apoptotic proteins and up-regulating pro-apoptotic factors like Bax, which leads to the cleavage of PARP and subsequent cell death in targeted cancer cells. Its action also extends to inhibiting adipocyte differentiation by suppressing the expression of PPARγ and leptin, highlighting its role in metabolic regulation.

2.PRODUCT INDICATIONS

Yakuchinone A is indicated for research applications focused on anti-inflammatory, anticancer, and anti-adipogenic studies. It is particularly suitable for investigating skin cancer models, including non-melanoma skin cancer, due to its selective cytotoxicity against these cell lines. Researchers utilize it to study autoimmune conditions like experimental autoimmune encephalomyelitis (EAE) and inflammatory skin diseases such as psoriasis, where it demonstrates efficacy in reducing inflammatory cytokines and chemokines. The product is also applied in studies related to metabolic disorders, specifically for its ability to inhibit lipid accumulation and adipogenesis in cell models.

3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, Yakuchinone A has demonstrated significant clinical efficacy in reducing inflammation and tumor growth. In mouse models of autoimmune encephalomyelitis, administration of Yakuchinone A led to a marked reduction in disease symptoms, indicating its potential for treating neuroinflammatory conditions. It has shown strong antitumor activity against various cancer cell lines, with notable efficacy in skin cancer models where it induces apoptosis and inhibits cell proliferation. Furthermore, its antioxidant properties and ability to scavenge free radicals contribute to its protective effects against oxidative stress, supporting its use in research aimed at developing therapeutic agents for inflammatory and neoplastic diseases.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553