TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Ziconotide Acetate |
| CAS NO. | 107452-89-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C102H172N36O32S7 |
| Molecular Weight | 2639.2 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; sparingly soluble in DMSO |
| Endotoxin | ≤0.05 EU/mg |
| Biological Activity | Potent N-type calcium channel blocker; inhibits synaptic transmission in pain pathways |
| Storage Conditions | Store at -20°C, protected from light; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Ziconotide exerts its analgesic effect by selectively and reversibly blocking N-type voltage-gated calcium channels (Cav2.2) located on the primary nociceptive afferent neurons in the dorsal horn of the spinal cord. This blockade inhibits the influx of calcium that is necessary for the release of pro-nociceptive neurotransmitters—such as glutamate, substance P, and CGRP—from the presynaptic terminals. By interrupting this key step in the pain signaling pathway, it effectively reduces the transmission of pain signals to the brain without affecting the central opioid receptors, distinguishing it mechanistically from traditional narcotics.
2.PRODUCT INDICATIONS
This product is FDA-approved for the management of severe chronic pain in adult patients who require intrathecal therapy and are intolerant or refractory to other treatments, including systemic analgesics and intrathecal morphine. It is particularly suited for complex pain conditions such as neuropathic pain, cancer-related pain, and pain associated with failed back surgery syndrome or multiple sclerosis. Due to its significant neuropsychiatric side effect profile and invasive administration route, its use is restricted to patients under close medical supervision by clinicians experienced in intrathecal drug delivery, typically after a comprehensive risk-benefit assessment.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Ziconotide, Prialt, IntrathecalAnalgesic, NonOpioid, ChronicPain, PainManagement, CalciumChannelBlocker, Conotoxin, NeuropathicPain, CancerPain, Supplier, Manufacturer, Bulk order, Pharmaceutical.
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