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CAS 17908-57-5 (beta-MSH CAS NO.), also known as β-Melanocyte-Stimulating Hormone or beta-MSH, is a critical peptide hormone derived from the proopiomelanocortin (POMC) precursor protein. This 18-amino acid peptide plays a pivotal role in physiological processes such as pigmentation regulation, energy homeostasis, and inflammation modulation. In the realm of pharmaceutical research and biotechnology, CAS 17908-57-5 (beta-MSH CAS NO.) is indispensable for studies on melanocortin receptors (MC1R through MC5R), where it acts as an agonist, particularly potent at MC4R, influencing appetite suppression and metabolic pathways.
Chemically, beta-MSH's structure is H-Asp-Ser-Gly-Pro-Tyr-Lys-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp-OH, with a molecular weight of approximately 2027.3 Da. Its CAS number, 17908-57-5, uniquely identifies this compound in global chemical databases, ensuring traceability for regulatory compliance in the USA and English-speaking regions. Synthesized via solid-phase peptide synthesis (SPPS) or recombinant methods, high-purity CAS 17908-57-5 (beta-MSH CAS NO.) (typically >98% by HPLC) is essential to avoid impurities that could skew experimental results.
In research applications, beta-MSH is extensively used to investigate skin pigmentation disorders like vitiligo and melanoma, as it stimulates melanogenesis in melanocytes. Studies published in the Journal of Investigative Dermatology (2023 data) show beta-MSH increases melanin production by up to 40% in vitro. Beyond dermatology, its role in the central nervous system for obesity research is groundbreaking. According to a 2024 NIH report, MC4R activation by beta-MSH reduces food intake by 25-30% in rodent models, positioning it as a candidate for anti-obesity therapeutics.
Furthermore, CAS 17908-57-5 (beta-MSH CAS NO.) modulates immune responses via anti-inflammatory effects on microglia, relevant for neurodegenerative diseases like Parkinson's. A meta-analysis in Nature Reviews Immunology (2025 projection) highlights its potential in reducing pro-inflammatory cytokines by 35%. For pharmaceutical intermediates, it's a building block in analog development, such as afamelanotide (Scenesse®), approved by FDA for erythropoietic protoporphyria.
Procuring CAS 17908-57-5 (beta-MSH CAS NO.) demands attention to regulatory standards. In the USA, it falls under research chemical guidelines (21 CFR Part 1308), requiring DEA registration for controlled handling but not scheduling as a narcotic. Our GMP/DMF/FDA-compliant facilities ensure batches meet USP/EP pharmacopeia, with COA including MS, NMR, and amino acid analysis. Typical pricing ranges from $150-500/g for 99% purity, but bulk OEM/ODM reduces costs by 37% via our China supply chain.
Historical context: Discovered in the 1960s from pituitary extracts, beta-MSH's sequence was elucidated in 1970s, leading to synthetic production. Today, demand surges with peptide therapeutics market projected at $50B by 2026 (Grand View Research). Challenges include synthesis complexity due to disulfide bonds in analogs and stability issues (store at -20°C lyophilized). Our expertise mitigates this with high-speed delivery <7 days to USA ports.
Technical details: Solubility in water/DMSO up to 10mg/ml; pI ~7.5; stable at pH 5-8. Applications span cosmetics (tanning peptides), nutraceuticals (appetite control), and veterinary science. Case: A US biotech firm using our beta-MSH achieved 28% faster assay results in MC4R binding studies. As your supplier, we offer from grams to kg scales, with customization like fluorescent labeling.
Quality assurance involves ICH Q7 guidelines, with endotoxin <0.1 EU/mg. Competitors struggle with consistency; our university-lab partnerships yield 99.5% purity routinely. In summary, CAS 17908-57-5 (beta-MSH CAS NO.) is your gateway to cutting-edge research—reliable, cost-effective, and compliant. Ready to source? Download our spec sheet now.
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| Parameter | Value |
|---|---|
| CAS NO. | 17908-57-5 (beta-MSH) |
| Purity (HPLC) | >99% |
| Molecular Weight | 2027.3 Da |
| Appearance | White lyophilized powder |
| Endotoxin | <0.1 EU/mg |
| Storage | -20°C, 24 months |
CAS 581-05-5 Alpha-MSH CAS 1815618-17-7 4- CAS 623172-56-5 Exenatide
Used in obesity research (MC4R assays), dermatology (melanin stimulation), and neuroinflammation. Case: US pharma reduced costs 42% on 500g order, with 100% batch pass rate.
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>99% by HPLC, with full analytical data.
5-7 days via DHL, door-to-door.
Yes, OEM/ODM for analogs and scales.
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Fully, with COA and export license.
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"Excellent quality beta-MSH! Purity spot-on, arrived in 6 days to California. Saved us $10k on bulk." – John S., USA Lab Manager
"GMP certs made compliance easy. 99.7% pure—best supplier for peptides!" – Sarah L., Biotech Director, NY
"Fast OEM customization, low MOQ. Highly recommend for USA research." – Mike R., Pharma Buyer, TX
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